2 edition of Identification of the major ionic currents in vascular smooth muscle cells. found in the catalog.
Identification of the major ionic currents in vascular smooth muscle cells.
Bradley John Bolzon
Written in English
|The Physical Object|
|Number of Pages||229|
Structure. Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels.. Nerve supply. Vascular smooth muscle is innervated primarily by the sympathetic nervous system through adrenergic receptors (adrenoceptors). The three types of adrenoceptors present are: main endogenous agonist of these cell MeSH: D Molecular identification of P2X receptors in vascular smooth muscle cells from rat anterior, posterior, and basilar arteries. Harhun MI(1), Sukhanova K(2), Gordienko D(2), Dyskina Y(2).Cited by: 3.
Previous work showed that vascular smooth muscle cells (VSMCs), macrophages, and multinucleated cells participate in atheroma plaque formation and progression and Cited by: 3. Formed Elements - 40% of blood volume, contains red blood cells, white blood cells, platelets, all of which are made in bone marrow Diagram the flow of blood through the mammalian circulatory system Blood flows into the right ventricle and atrium before moving to the lungs and back into the left atrium and ventricle where it is pushed out of.
Abstract K + channels and their currents are important in vascular tone regulation and are potential therapeutic targets; however, K + channels in human coronary artery vascular smooth muscle cells (VSMCs) have received little attention. We examined K + currents in freshly isolated VSMCs from human coronary arteries (n= from 32 human hearts) with conventional patch-clamp or perforated-patch Cited by: Smooth muscle is an involuntary non-striated is divided into two subgroups; the single-unit (unitary) and multiunit smooth muscle. Within single-unit cells, the whole bundle or sheet contracts as a syncytium.. Smooth muscle cells are found in the walls of hollow organs, including the stomach, intestines, urinary bladder and uterus, and in the walls of passageways, such as the FMA:
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Klöckner U, Isenberg G. Action potentials and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea-pig). Pflugers Arch. Dec; (4)– Klöckner U, Isenberg G.
Calcium currents of cesium loaded isolated smooth muscle cells. Lang RJ () Identification of the major membrane currents in freshly dispersed single smooth muscle cells of guinea-pig ureter.
J Physiol (Lond) – Google Scholar Langton PD, Burke EP, Sanders KM () Participation of Ca currents in colonic electrical by: 5.
Walsh JV, Jr, Singer JJ. Voltage clamp of single freshly dissociated smooth muscle cells: current-voltage relationships for three currents. Pflugers Arch. May; (2)– Walsh JV, Jr, Singer JJ.
Identification and characterization of major ionic currents in isolated smooth muscle cells using the voltage-clamp by: Clear identification of the smooth muscle cell and assessment of its state of differentiation must rely on multiple criteria, including expression of multiple smooth-muscle-cell selective proteins, the morphologic and functional characteristics of the cell, and, at least in vivo, the anatomical location of the cell.
Isenberg, G., and Klöckner, U.,Calcium currents of smooth muscle cells isolated from the urinary bladder of the guinea-pig: inactivation, conductance and selectivity is controlled by micromolar amounts of [Ca] o, J.
Physiol. (Lond.) P. Google ScholarCited by: 3. Altered handling of ions by the vascular muscle membrane is viewed as a potential mechanism contributing to the development and maintenance of high blood pressure. This hypothesis is based on the premise that disturbances in membrane function may enhance vascular reactivity and increase total peripheral by: 6.
This book contains the contributions and discussions of the second symposium on vascular smooth muscles held in Ttibingen in February, It provides an up-to-date review of the role of ions in the trans mission of signals from the perivascular space to the contractile ele ments of the smooth muscle cells.
Identification of the Ca2+ current activated by vasoconstrictors in vascular smooth muscle cells. Van Renterghem C(1), Lazdunski M. Author information: (1)Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, by: A. DUVALANDC. LLOTY mammalian skeletal muscles. So the aim of the present experiments was to investigatethe changes in ionic conductances ofrat skeletal muscle.
Thedoublesucrose-gap methodwasmodifiedin suchawaythatit appearedtobe satisfactory for voltage clamping isolated muscle cells even when early current develops (Leoty &Poindessault, ; Leoty&Alix, ).). Cited by: Purinergic P2X receptors in vascular smooth muscle cells (VSMCs) play an important role in physiological stimulatory responses to the extracellularly released ATP.
The aim of this work was to identify molecular P2X receptor subunits in VSMCs isolated from rat anterior, posterior and basilar arteries using a number of contemporary laboratory Cited by: 3. The effects of intracellularly perfused ATP and cyclic-AMP (c-AMP) on ionic currents recorded from fragmented smooth muscle cells (smooth muscle ball; SMB) were investigated, using the single electrode whole cell voltage clamp method.
The Ca 2+ current was distinguished from K + currents, using pipette solution containing Cs +, TEA + and 4 mM by: Voltage-dependent inward currents responsible for the depolarizing phase of action potentials were characterized in smooth muscle cells of 4th order arterioles in mouse skeletal : Alexandra Ulyanova.
It was concluded that the outward rectifying potassium current in MSI smooth muscle cells is mediated by a pS bursting channel.
Voltage dependency and Ba2+ blockade are mainly reflected by changes in the transition rate from the open channel state to the interburst closed by: This book contains the contributions and discussions of the second symposium on vascular smooth muscles held in Ttibingen in February, It provides an up-to-date review of the role of ions in the trans mission of signals from the perivascular space to the contractile ele ments of the smooth muscle : Kindle.
Identification of the major ionic currents in single cells isolated from the rat ureter provided a detailed description showing that in rat vascular smooth muscle cells a decrease in. Vascular Smooth Muscle Contraction and Relaxation The contractile characteristics and the mechanisms that cause contraction of vascular smooth muscle (VSM) are very different from cardiac muscle.
VSM undergoes slow, sustained, tonic contractions, whereas cardiac muscle contractions are rapid and of relatively short duration (a few hundred. Ion channels in the plasma membrane and endoplasmic reticulum of vascular smooth muscle cells (SMCs) in these blood vessels importantly contribute to the regulation of intracellular Ca 2+ concentration, the primary determinant of SMC contractile activity and vascular by: Angela Wirth, Stefan Offermanns, in Muscle, Smooth muscle cells in the wall of many hollow organs like the bronchial, vascular, gastrointestinal or urogenital system, play a central role in organ function under physiological and pathophysiological conditions.
The tone of smooth muscle cells is under the control of numerous factors that are produced and released locally as well as.
in skeletal muscle, it does not bind directly to ion channels on “smooth muscle” cells of internal organs. In smooth muscle, acetylcholine exerts its effects through “second messengers” instead.
Ion currents and potentials page 3 Ed MrozFile Size: KB. Research projects conducted in my laboratory are focused on studying the roles, regulation, properties and molecular basis of potassum and non-selective cation channels in vascular smooth muscle.
In particular, our major interests concern the voltage-gated and ATP-sensitive potassium, and transient-receptor potential non-selective cation.
In addition, other ionic currents via T-type Ca channels, the Na +-Ca ++ exchanger and a sustained inward Na + current were detected in SA node cells. In later studies a timing mechanism composed of ionic channels in the plasma membrane and the sarcoplasmic reticulum (SR) membrane .Ionic channels in vascular smooth muscle.
Ionic currents in vascular smooth muscle --Properties of different types of channels in VSM pS single K channel using the cell-attached configuratioon --Angiotensin II blocked the macroscopic delayed outward K current in single aortic cells of the rabbit --Possible role of Ca²⁺ and K.In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells.
These signals vary with respect to their mechanisms of generation.